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By Joshua Mitteldorf

Because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary conception, specially within the sector of genetics. at the same time, a technology of multilevel choice has chanced on its position within the evolutionary literature. the writer means that proof warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic conception of senescence, wherein getting older has Read more...

summary: because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary conception, in particular within the quarter of genetics. simultaneously, a technological know-how of multilevel choice has stumbled on its position within the evolutionary literature. the writer means that facts warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic concept of senescence, wherein getting older has been affirmatively chosen since it degrees the dying expense over the years, aiding to stabilize inhabitants dynamics and stop extinctions

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Extra resources for Aging is a group-selected adaptation: theory, evidence, and medical implications

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Evolution Int. J. Org. Evolution, 2000. 54(3): p. 740-50. 24. , Overview of caloric restriction and aging. Mech. , 2005. 126(9): p. 913-22. 25. J. and B. Sears, Low-glycemic-load diets: impact on obesity and chronic diseases. Crit. Rev. Food Sci. , 2003. 43(4): p. 357-377. 26. , Protein restriction (PR) and caloric restriction (CR) compared: effects on DNA damage, carcinogenesis and oxidative damage. Mutation Research/DNAging, 1993. 295(4): p. 165-179. 27. , Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

Sketchy but promising results from blood analysis of human volunteers suggest that intermittent fasting can promote a younger metabolism [3234]. Some field clinicians report promising health results with diets for seniors based on periods of severely restricted food, alternating with ad libitum access [35]. Hormesis 9 McCay’s original studies emphasized an abundance of micronutrients in the context of a low-calorie diet. The wisdom of this approach was not questioned for fifty years, and indeed micronutrients have long been considered an unmitigated boon to good health.

181-192. 35. A. K. Hellerstein, Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am. J. Clin. , 2007. 86(1): p. 7-13. 36. P. and D. Albanes, The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N. Engl. J. , 1994. 330(15): p. 1029-35. 37. , M. Down, and R. Sen, The effects of vitamin E and training on physiological function and athletic performance in adolescent swimmers.

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