Download Aging Methods and Protocols by Yvonne A. Barnett, Christopher R. Barnett PDF

By Yvonne A. Barnett, Christopher R. Barnett

Getting older equipment and Protocols offers a couple of state of the art protocols, defined via famous specialists of their box, that are getting used to additional our knowing of the getting older strategy. those certain biochemical, actual and molecular biology ideas are mixed to supply a very good source for researchers and scientists from a wide selection of disciplines. additionally incorporated is a presentation of 2 case reviews that target the position of nutritional limit in existence span extension, in addition to how you can determine and make the most of transgenic animals for the elucidation of the molecular elements of getting older. This e-book is a useful resource of state of the art learn protocols with large clinical applicability and may curiosity clinical researchers, clinicians concerned inIn this paintings, specialists aspect key biochemical, analytical, and molecular ideas for the research of getting older on the mobile, tissue, organ, and entire procedure degrees.

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D. (1989) Growth factors as probes of cell aging. Exp. Gerontol. 24, 367–374. 44. , Phillips, P. , and Cristofalo, V. J. (1986) The effect of dexamethasone on epidermal growth factor binding and stimulation of proliferation in young and senescent WI38 cells. Exp. Cell Res. 164, 408–414. 45. , and Cristofalo, V. J. (1993) Effect of the tumor promotor phorbol 12-myristate 13-acetate (PMA) on proliferation of young and senescent WI-38 human diploid fibroblasts. Exp. Cell Res. 205, 261–269. 46. Goodman, L.

Cell. Physiol. 162, 277–283. 20. Keogh, B. , Cristofalo, V. , and Allen, R. G. (1995) Effects of cellular aging on the induction of c-fos by antioxidant treatments. Mech. Ageing Dev. 86, 151–160. 21. Levy, M. , Allsopp, R. , Futcher, A. , Greider, C. , and Harley, C. B. (1992) Telomere end-replication problem and cell aging. J. Mol. Biol. 225, 951–960. 22. , and Lotze, C. (1995) Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence? Exp. Cell Res. 220, 186–192.

The T-cells to be cloned were derived from young adult donors and were mostly prestimulated with alloantigens. Under these conditions, the type of T-cell predominantly derived was CD4+ and carried the α/β T-cell receptor (TCR2). This chapter therefore focuses on this type of TCC, and not on CD8 or TCR1 cells, which seem to behave somewhat differently in culture, but which we have not studied so extensively. For meaningful studies of T-cell aging in vitro, it is essential to know the in vivo age of the starting T-cell population.

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