Download Analgesia by Christoph Stein, Christoph Stein PDF

By Christoph Stein, Christoph Stein

This quantity makes an attempt to summarize the present kingdom of information on mechanisms underlying many of the results of analgesics, their aspect impact profiles, and their symptoms and contraindications in medical use. It additionally supplies insights into present efforts to find novel mechanisms underlying the new release of other varieties of ache and the ensuing improvement of latest modulating compounds.

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Example text

3 Clinical Applications . . Acute Pain . . . . . Chronic Pain . . . . Pharmacokinetics . . . Absorption . . . . . Distribution . . . . Metabolism and Excretion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

49 49 49 49 50 50 51 51 51 52 52 . . . . . . . . . . . . . . . . . . . . . 32 C. Zöllner · C. 2 Chronic Opioid Application . . . . . . . . . . . .

4a An autoradiographic receptor binding technique showing the distribution of μreceptors within rat brain slices. An increase in μ-receptor density (indicated with arrows) shows their distribution in various regions, including the cortex, thalamus, hypothalamus, and brainstem. b Immunocytochemical studies showing μ-receptors within laminae I–II of spinal cord dorsal horns from rats (kindly provided by Dr. S. Mousa). c Immunocytochemical studies from rat hindpaw preparations indicating μ-receptors on primary afferent neurons (also kindly provided by Dr.

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