Download Biologically Active Molecules: Identification, by Wolfgang Steglich (auth.), Prof. Dr. Urs Peter Schlunegger PDF

By Wolfgang Steglich (auth.), Prof. Dr. Urs Peter Schlunegger (eds.)

Over the earlier few years there was a impressive and fast improvement of recent analytical tools, and the fields of nuclear magnetic resonance and mass spectrometry were no exception. as well as with the ability to do "more and faster", new cutting edge innovations have additionally arisen to give a contribution to a starting to be realizing of the connection among chemical constitution and organic task. on the way to discover some of the extra fascinating issues of these advancements and functions, a seminar "From organic job to constitution" was once equipped from September 5-7, 1988, at Interlaken. The 4 invited audio system, Richard M. Caprioli, Howard R. Morris, Wolfgang Steglich and Dudley H. Williams have been type sufficient to wait and talk about many elements in their study, specifically methodological and technical advancements and their functions to express difficulties. members have been brought to non-stop move FAB (fast atom bombardment) and its use, for instance, within the genuine time tracking of biochemical reactions in vitro and in vivo; the structural elucidation of secondary metabolites from fungi; the research of molecule-receptor interactions; the selection of posttranslational adjustments of peptides; and the positioning of S-S bridges in making a choice on the tertiary constitution of proteins.

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Read Online or Download Biologically Active Molecules: Identification, Characterization and Synthesis Proceedings of a Seminar on Chemistry of Biologically Active Compounds and Modern Analytical Methods, Interlaken, September 5–7, 1988 PDF

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Extra resources for Biologically Active Molecules: Identification, Characterization and Synthesis Proceedings of a Seminar on Chemistry of Biologically Active Compounds and Modern Analytical Methods, Interlaken, September 5–7, 1988

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5er - - -- - - .... .... " '_+I____________~h~iS~________~_____ - MoH .... , ,- , .... ~ n. Figure 2. 11- ... m/z ... The positive ion FAB mass spectrum of a peptide fragment from the LHRH protein. does occur, fragment ions are of relatively low intensity and, generally, sequence specific ions are not reliably observed in the FAB spectrum. Nevertheless, the production of an intense molecular ion from a completely underivitized and charged compound such as a 45 peptide, in many cases up to molecular weights of 7,000 or 8,000 daltons, is extremely valuable to the biochemist.

Pommer, H. Sauter and U. Schirmer, BASF AG, are greatly appreciated. REFERENCES 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Anke T, Oberwinkler F, Steglich W, Schramm G (1977) J Antibiot 30:806 Schramm G, Steglich W, Anke T, Oberwinker F (1978) Chem Ber 111:2779 Anke T, Schramm G, Schwalge B, Steffan B, steglich W (1984) Liebigs AnnChem: 1616 Grant OM, Paul G (1964) J Am Chem Soc 86:2984 Klebe G, BASF AG, Ludwigshafen, unpublished. We thank Dr. Klebe for the X-ray structure determination. Anke T, Hecht HJ, Schramm G, Steglich W (1979) J Antibiot 32:1112 Schramm G (1980) Dissertation Universitat Bonn Meyer HH (1984) Liebigs Ann Chem: 791 Akita H, Koshiji H, Furuichi A, Horikoshi K, Oishi T (1983) Tetrahedron Lett 24: 2009 Musilek V, Cerna J, Sasek V, Semerdzieva M, Vondracek (1969) Folia Mikrobiol (Prague) 14:377 Vondra~ek M, capkova J, Slechta J, Benda A, Musilek V, Cudlin J (1971) Czech Pat 136495; CA 75:4029n Sedmera P, Musilek V, Nerud F, Vondracek M (1981) J Antibiot 34:1069 v Jagow G, Gribble GW, Trumpower B (1986) Biochemistry 25:775 Bauerle J (1981) Dissertation Universitat Tubingen Anke T, Besl H, Mocek U, Steglich W (1983) J Antibiot 36:661 25 11 Vondracek M, capkova J, Slechta J, Benda A, Musilek V, Cudlin J (1971) Czech Pat 136495; CA 75:4029n 12 Sedmera P, Musilek V, Nerud F, Vondra~ek M (1981) J Antibiot 34:1069 13 v Jagow G, Gribble GW, Trumpower B (1986) Biochemistry 25:775 14 Bauerle J (1981) Dissertation Universitat Tubingen 15 Anke T, Besl H, Mocek U, steglich W (1983) J Antibiot 36:661 16 Vondra~ek M, Vondra~kova J, Sedmera P, Musilek V (1983) Coll Czech Chem Commun 48:1508 17 Anke T, Scherer A, Steglich W, in preparation 18 Backens S, steglich W, Bauerle J, Anke T (1988) Liebigs Ann Chem:405 19 Nerud F, Sedmera P, Zouchov~ Z, Musilek V, Vondra~ek M (1982) Coll Czech Chem Commun 47:1020 20 Beautement K, Clough JM (1987) Tetrahedron Lett 28:475 21 Nakata T, Kuwabara T, Tani Y, oishi T (1982) Tetrahedron Lett 23:1015 22 Kowalski CJ, Haque MS, Fields KW (1985) J Am Chem Soc 107:1429 23 Wittman MD, Kallmerten J (1987) J Org Chem 52:4303 24 Burke SD, Fobare WF, Pacofsky GJ (1983) J Org Chem 48:5221; Kallmerten J, Gould TJ (1983) Tetrahedron Lett 24:5177 25 Buss AD, Mason R, Warren S (1983) Tetrahedron Lett 24:5293 26 Akita H, Matsukara H, Oishi T (1986) Tetrahedron Lett 27:5397 27 Subik J, Behun M, Musilek V (1974) Biochem Biophys Res Commun 57:17 28 Douros J, National Cancer Institute, USA, personal communication.

Most often isolation of the activity of interest is done first using methods which are based on extraction, chromatography, electrophoresis or other types of physical separation and purification procedures. The bioactive molecule can be followed by a bioassay and/or by a chemical or physical property of the compound. Over the years optical spectroscopy has played a key role in this regard, for example, an amino acid analysis for a protein involves the reaction of the amino group with ninhydrin to form a colored product, or the base analysis of nucleic acids which employs the absorption of light at a wave length of 254 nanometers.

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