By Desmond N. Carney, Adi F. Gazdar, Herbert K. Oie (auth.), F. Anthony Greco (eds.)
Lung melanoma continues to be an exceptionally tricky neoplasm to regard successfully. a wide a part of our loss of good fortune in facing those sufferers is said to our empiric healing makes an attempt. Slowly our uncomplicated realizing of the lung cancers is enhancing and methods have gotten to be had to permit us to raised comprehend the biology of those neoplasms. This quantity studies numerous components of curiosity in regard to the biologic habit and characteris of lung melanoma. tics Chapters take care of the in vitro development of small mobile lung melanoma, the inves tigation of development elements in human lung melanoma, the construction of mono clonal antibodies opposed to lung melanoma and the appliance and strength use fulness of the human tumor cloning assay in lung melanoma administration. those avenues of research are inclined to identify a extra medical foundation on which extra rational remedy may be designed. Carney and co-workers have proven numerous non-stop small telephone lung melanoma mobilephone traces of their laboratory. The amine precursor uptake and decar boxylation (APUD) houses of this neoplasm were proven by means of demonstrating the presence of neurosecretory granules and excessive degrees of the APUD enzyme L-dopa decarboxylase. moreover, a number of new markers were documented together with bombesin, creatine-kinase BB and neuron particular enolase. those tumor items besides others can be helpful serum markers in sufferers with small phone lung cancer.
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FURTHER CHARACTERIZATION OF MONOCLONAL ANTIBODIES SELECTIVE FOR HUMAN SCLC Those hybridomas fulfilling the requirements of our initial screening restrictions were further assessed for their binding specificity. Our first approach in evaluating these reagents was to see if their selective binding was maintained when tested against different SCLC lines. Figure 2 represents the binding titration curve of a mouse monoclonal antibody (534F8) on three autologous pairs of cell lines. -25 ,... ; 10 '0...
Cancer Res 42: 150-154, 1982. 18. Brenner BG, Jothy S, Shuster J, Fuks A: Monoclonal antibodies to human lung tumor antigens. Cancer Res 1982 (in press). 19. Minna JD, Higgins GA, Glatstein EJ: Cancer of the lung. In: Principles and Practice of Oncology. DeVita VT, et al. (eds). Philadelphia: JB Lippincott, 1981, pp 396-473. 20. Gazdar AF, Carney DN, Guccion JG, Baylin SB: Small cell carcinoma of the lung: cellular origin and relationship to other pulmonary tumors. In: Small Cell Lung Cancer. Greco FA, et al.
TODARO 1. INTRODUCTION Growth factors are substances which stimulate cell division in a variety of target tissues [1, 2]. Such factors include low molecular weight polypeptides such as epidermal growth factor, platelet-derived growth factor, fibroblast growth factor, and the insulin growth factors, and relatively higher molecular weight glycoproteins such as colony stimulatory factors, which act primarily on hematopoietic stem cells [3-8]. There is increasing evidence that growth factors playa role in normal embryogenesis as well as in the regeneration of normal tissues in the adult .