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By Khorshed M. Pavri

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32 . CHALLENGE OF AIDS and is called p24 (Fig. 10). The p l 7 (pl8) core protein covers the internal surface of the envelope. The envelope is a two-layered lipid or fatty coat. The lipid material is derived from the outer membrane of the host cell acquired during the budding process. The envelope proteins have attached sugar chains and are thus called glycoproteins (gp). The knob-like structure is gp 120; the one which sits on the membrane is called the transmembrane glycoprotein identified as gp 41 on the basis of the molecular weights.

CHALLENGE OF AIDS and is called p24 (Fig. 10). The p l 7 (pl8) core protein covers the internal surface of the envelope. The envelope is a two-layered lipid or fatty coat. The lipid material is derived from the outer membrane of the host cell acquired during the budding process. The envelope proteins have attached sugar chains and are thus called glycoproteins (gp). The knob-like structure is gp 120; the one which sits on the membrane is called the transmembrane glycoprotein identified as gp 41 on the basis of the molecular weights.

The HLA antigens are hereditary components of these cells. Antigen Presenting Cells (APC) Cells of monocyte/macrophage lineage, which act as scavengers through phagocytosis, also act as APC. Another cell of the same lineage, called dendritic cell (Fig. 17), resides in the skin, mucosal tissues, lymph nodes and the spleen. The fact that antigens are encountered first and also most (frequently) in these areas, has imparted a very important role as APC to the dendritic cells. B cells also act as APC, particularly efficiently when activated.

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