By G. E. W. and O'Connor, Cecilia M. Wolstenholme
Chapter 1 establishing feedback (pages 1–2):
Chapter 2 Synthesis and houses of Purines of power organic curiosity (pages 3–19): Aaron Bendich, Alfredo Giner?Sorolla and Jack J. Fox
Chapter three a few man made stories on Purines and comparable Heterocycles (pages 20–38): E. C. Taylor, T. S. Osdene, E. Richter and O. Vogl
Chapter four a few New N?Methylpurines (pages 39–49): Gertrude B. Elion
Chapter five The constitution of the Hydroxypurines Investigated via O? and N?Methylation (pages 50–59): D. J. Brown
Chapter 6 The Spectra and constitution of the Monohydroxypurines and different in all likelihood Tautomeric Purines (pages 60–71): S. F. Mason
Chapter 7 The ??Electron homes of Purine Calculated by means of the L.C.A.O. strategy (pages 72–76): S. F. Mason
Chapter eight The Degradation of Uric Acid through Water stressed (pages 77–96): Wolfgang Pfleiderer
Chapter nine The 8?Position in Purines. The Chemical and organic Transformation of Purines Into Pteridines (pages 97–107): Adrien Albert
Chapter 10 Cyclonucleosides (pages 108–119): D. M. Brown, Sir Alexander Todd and S. Varadarajan
Chapter eleven Stereochemistry of Nucleoside Synthesis (pages 120–133): B. R. Baker
Chapter 12 man made Chemical Investigations regarding the Metabolism of Purines (pages 134–145): G. M. Timmis, I. Cooke and R. G. W. Spickett
Chapter thirteen the results of strength Antipurines on a Purine?Requiring pressure of Escherichia coli (pages 146–159): H. O. J. Collier and Patricia L. Huskinson
Chapter 14 The Chemistry of recent Purines within the B (pages 160–168): E. Lester Smith
Chapter 15 organic and Microbiological task of Purine Analogues of diet B (pages 169–176): S. okay. Kon
Chapter sixteen Puromycin (pages 177–191): Brian L. Hutchings
Chapter 17 Chemical and organic Behaviours of 9???d?Ribofuranosylpurine (pages 192–203): G. B. Brown, M. P. Gordon, D. I. Magrath and A. Hampton
Chapter 18 at the Activation of the One?Carbon Unit for the Biosynthesis of Purine Nucleotides (pages 204–232): G. Robert Geeenberg and Lothar Jaenicke
Chapter 19 The Enzymatic Synthesis of Inosinic Acid De Novo (pages 233–255): J. M. Buchanan, J. G. Flaks, S. C. Hartman, B. Levenberg, L. N. Lukens and L. Warren
Chapter 20 Enzymic keep watch over of Purines via Xanthine Oxidase (pages 256–269): F. Bergel, R. C. Bray, A. Haddow and that i. Lewin
Chapter 21 The organic results of 8?Azapurines (pages 270–285): R. E. F. Matthews
Chapter 22 Biochemical results of 6?Mercaptopurine (pages 286–308): Gertrude B. Elion and George H. Hitchings
Chapter 23 using 6?Mercaptopurine within the remedy of Leukaemia (pages 299–307): D. A. G. Galton
Chapter 23 basic dialogue (pages 308–317):
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Extra resources for Ciba Foundation Symposium - Chemistry and Biology of Purines
P. (1954). Ann. N . Y . Acad. ,60, art. 2. HOTCHKISS, R. (1948). J . biol. , 175, 315. JOHNS, C. , and HENDRIX,B. M. (1915). J . biol. , 20, 153. LORZ,D. , and HITCHINGS, G. H. (1950). Fed. , 9,197. MANN,F. , and PORTER, J. W. G. (1945). J . chem. ,751. MASON,S. F. (1954). J . chem. ,2071. TAYLOR, E. C. (1954). Ciba Foundation Symposium on Chemistry and Biology of Pteridines, p. 2. London: J. & A. Churchill Ltd. W. (1900). Ber. dtsch. chem. , 33, 3035. TRAUBE, TRAUBE, W. (1904). , 331,64. , and DUDLEY,H.
REFERENCES ALBERT, A. (1955). J . chem. ,2690. , and TODD,A. R. (1943). J . chem. ,383. BARRETT, H. , and DITTMER, K. (1948). J . Amer. chem. ,70, 1753. BEAMAN, A. G. (1954). J . A w . chem. ,76,5633. , and ROBL,R. , 423,200. , and MARTINI, A. (1948). BROWN, DlJ,, HOE 4035. 49 (1921). Ber. dtsch. chem. , CARTER, C. E. (1950). J. Amer. chem. ,72, 1466. CLARKE, D. , STOCK,C. , ELION,G. , and HITCHINGS, G. H. Unpublished data. ELION, G. , HITCHINGS, G. , and VANDERWERFF, H. (1951). J . biol. , 192,505.
Pharm. Chemi, 244,11. WOOD,H. C. S. (1954). Ciba Foundation Symposium on Chemistry and Biology of Pteridines, p. 35. London: J. & A. Churchill Ltd. [Discussion of this paper was postponed until after the paper by Dr. D. J. ] THE STRUCTURE OF THE HYDROXYPURINES INVESTIGATED BY 0- AND N-METHYLATION D. J. g. g. 11). As methyl groups are almost optically transparent, such information can be got, as for example in the pyrimidine series (Marshall and Walker, 1951 ; Brown and Short, 1958;Brown, Hoerger and Mason, 1955)by comparison of the ultraviolet spectra of the hydroxypurines with those of the corresponding methoxy and N-methyl-oxo derivatives.