Download Commercial Plant-Produced Recombinant Protein Products: Case by John A. Howard, Elizabeth E. Hood PDF

By John A. Howard, Elizabeth E. Hood

Attention has lately became to utilizing crops as hosts for the creation of commercially very important proteins. The twelve case reports during this quantity current profitable thoughts for utilizing crops to supply business and pharmaceutical proteins and vaccine antigens. They study intimately initiatives that experience advertisement power or items that experience already been commercialized, illustrating the benefits that vegetation provide over bacterial, fungal or animal cell-culture hosts. there are lots of symptoms that plant protein creation marks the start of a brand new paradigm for the economic construction of proteins that, over the following decade, will extend dramatically.

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One such study was to discover the characteristics of a protein fed to animals (Fig. 1). Were antibodies produced? E. A. 34 μM Identical Yes Identical 12,500 kDa Fig. 1 Western blot of feces extracts from mice fed various diets. Total protein was separated on a 12 % SDS polyacrylamide gel and proteins were blotted onto a PVDF membrane (Millipore). Detection of avidin was with an anti-avidin antibody and a secondary antibody conjugated to alkaline phosphatase (AP). AP was detected with a chemiluminescent substrate.

1079/ivp2001247 Teoh KT, Requesens DV, Devaiah SP, Johnson D, Huang X, Howard JA, Hood EE (2013) Transcriptome analysis of embryo maturation in maize. BMC Plant Biol 13(1):19 Thompson RC, Eakin RE, Williams RJ (1941) The extraction of biotin from tissues. Science 94 (2451):589–590. 589 Wallen MJ, Laukkanen MO, Kulomaa MS (1995) Cloning and sequencing of the chicken egg-white avidin-encoding gene and its relationship with the avidin-related genes Avr1Avr5. Gene 161(2):205–209 White J, Chang SY, Bibb MJ, Bibb MJ (1990) A cassette containing the bar gene of Streptomyces hygroscopicus: a selectable marker for plant transformation.

These benefits include optimized glycans, versatility to adapt to market forces that cannot be satisfied with the current platforms (individualized therapies, rapid-response vaccines, bulk “commodity” antibody manufacturing), and unique properties of cereal seeds that provide an efficient strategy for oral vaccination. As further technical developments unfold, the number of market needs that can be met by plants will increase. For example, the combination of rapid response and bioencapsulation for oral vaccines could be met by the production of vaccine antigens in tobacco plastids, as recently shown for the production of coagulation factor IX in tobacco leaves and the subsequent demonstration that orally administered tobacco leaves can prevent anaphylactic reactions in a mouse model of hemophilia B (Verma et al.

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