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By Norman S. Wolf

Made up our minds through an lack of ability to maneuver according to contact. C. elegans boost via 4 larval phases following hatching and sooner than maturity. grownup C. elegans are reproductive for approximately the rst week of maturity via nearly weeks of post-reproductive maturity sooner than demise. lifestyles span is most typically measured within the laboratory via holding the worms at the floor of a nutrie- agar medium (Nematode development Medium, NGM) with E. coli OP50 because the bacterial nutrition resource (REF). substitute tradition stipulations were defined in liquid media; despite the fact that, those aren't favourite for durability reviews. sturdiness of the widely used wild style C. elegans hermaphrodite (N2) varies ? from sixteen to 23 days lower than ordinary laboratory stipulations (20 C, NGM agar, E. coli OP50 nutrition source). lifestyles span will be elevated through conserving animals at decrease ambient temperatures and shortened by way of elevating the ambient temperature. Use of a killed bacterial foodstuff resource, instead of dwell E. coli, raises lifespan via 2–4 days, and progress of grownup animals within the absence of micro organism (axenic development or bac- rial deprivation) raises median existence span to 32–38 days [3, 23, 24]. below either usual laboratory stipulations and bacterial deprivation stipulations, wild-derived C. elegans hermaphrodites convey durability corresponding to N2 animals [25]

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J Exp Biol 208: 1717–1730. 9. Harman D (1956). Aging: A theory based on free radical and radiation chemistry. J Gerontol 11: 298–300. 10. Sohal RS (1986) The rate of living theory: A contemporary interpretation. )). Insect Aging. Berlin: Springer-Verlag, pp. 23–44. 11. Pearl R (1928). The Rate of Living. A. Knopf. 12. Rubner M (1908). Das Problem der Lebensdauer und seine Beziehungen zum Wachstum und Ernahrung. Munich: Oldenbourg. 13. Kleiber M (1956). Energy metabolism. Annu Rev Physiol 18: 35–52.

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Syst Biol 41: 18–32. 19. de Magalhaes JP, Costa J, and Church GM (2007a). An analysis of the relationship between metabolism, developmental schedules, and longevity using phylogenetic independent contrasts. J Gerontol A Biol Sci Med Sci 62: 149–160. 20. Lambert AJ, Boysen HM, Buckingham JA, Yang T, Podlutsky A, Austad SN et al. (2007). Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell 6: 607–618. 21.

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