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By Howard M. Fillit MD

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Tangalos, E. , Smith, G. , & Kokmen, E (1997). Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology, 49, 786-794. Jack, C. , Petersen, R. , Xu, Y. , O'Brien, P. , Smith, G. , Ivnik, R. , Boeve, B. F, Waring, S. , Tangalos, E. , & Kokmen, E. (1999). Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology, 52,1397-1403. Jack, C. , Petersen, R. , Xu, Y, O'Brien, P. , Smith, G. , Ivnik, R. , Boeve, B. F, Tangalos, E. , & Kokmen, E.

Of critical relevance, successes in mapping genes for Wilson's disease and deafness using inbred Arab kindreds facilitated the cloning of these genes, which were subsequently shown to have diseasecausing mutations prevalent in outbred populations from other parts of the world, including the United States. All of the known Alzheimer-related genes (on chromosomes 21, 14, 1, and 19) are dominant (chromosomes 21,14,1) or codominant (chromosome 19). There are no known genes affecting the development of AD that are recessive, perhaps because there have been few studies of AD in populations with high levels of inbreeding.

Participants were questioned about their responses to the interview and the process. Results: Under conditions that might be present in many clinical practices, the acceptance/completion rate for telephonic mental status assessment among participants 75 years and older was 55% (190/348) among those actually contacted. Of those who underwent cognitive assessment, the yield of cognitively impaired participants was low (3%). Among the interviewees, willingness to consult 17 18 Early Detection x. ph p with a physician regarding memory problems detected during a telephonic screen was 87%.

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