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By K. Clive Thompson, Kirit Wadhia, Andreas Loibner

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Extra resources for Environmental Toxicity Testing (Sheffield Analytical Chemistry Series)

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Registration. Producers will be obliged to provide basic safety data, by fixed deadlines to authorities, on all chemicals produced in quantities above 1 tonne per year. Evaluation. For higher production volume chemicals above 100 tonnes, and for chemicals of concern, experts from Member States in association with a central co-ordinating body will evaluate the registration data. The evaluation may lead to authorisation (in the case of chemicals of ‘very high concern’), risk reduction (where dangerous uses are restricted) or no further regulatory action.

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There remain many challenges for these multiple lines of investigation and, despite the wealth of literature that continues to grow and the rapid advances in our understanding, there is a need to improve risk-based decision-making associated with the legislative framework for controlling chemicals. 2 Key references. 1984d, 1992a,b, 1998b, 2000b 1984c, 1998a, 1999b, 2000a 1984b, 1999a 1984a OECD United States Environmental Protection Agency 1985, 1989a,b, 1991, 1992, 1993a,b,c, 1994b,c, 1995 Environment Canada 1998b, 2000a,b, 2001, 2002 Environment Canada 1990a,b, 1992b,e, 1998a,b Environment Canada 1990c, 1992a,e Environment Canada 1992d, 1999 Environment Canada 1992c Other HISTORICAL PERSPECTIVE AND OVERVIEW 13 the needs of the end-user, and effective dialogue between scientists, policy-makers and operational staff will enhance our understanding and underpin decisionmaking with sound science.

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