Download Glycosylphosphatidylinositol (GPI) Anchoring of Proteins by Anant K. Menon, Peter Orlean, Taroh Kinoshita and Fuyuhiko PDF

By Anant K. Menon, Peter Orlean, Taroh Kinoshita and Fuyuhiko Tamanoi (Eds.)

This quantity of The Enzymes beneficial properties high-caliber thematic articles relating to glycosylphopshatidylinositol (GPI) anchoring of proteins. * Contributions from prime gurus * Informs and updates on all of the newest advancements within the box

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51. J. (1994). Genomic organization of the X-linked gene (PIG-A) that is mutated in paroxysmal nocturnal hemoglobinurea and of a related autosomal paseudogene mapped to 12q21. Human Mol Genet 3:751–757. 52. , and Kinoshita, T. (1997). Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. Genomics 44:347–349. 53. , and Hirotsune, S. (2004). A new role for expressed pseudogenes as ncRNA: regulation of mrna stability of its homologous coding gene.

Abstract The N-acetylglucosamine phosphatidylinositol (GlcNAc-PI) de-N-acetylase catalyzes the removal of the N-acetyl group from GlcNAc-PI in the second step of GPI biosynthesis. The GlcNAc-PI de-N-acetylase is a 252-residue integral membrane protein containing a single N-terminal membrane spanning domain, with the majority of the protein on the cytoplasmic face of the ER. Site-directed mutagenesis studies have lead to the proposal of a zinc-dependent mechanism of action analogous to zinc peptidases.

1996). PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homolog of Saccharomyces cerevisiae GPI2. Biochem Biophys Res Commun 226:193–199. 46 DAVID E. LEVIN AND RONALD J. STAMPER 33. , and Fields, S. (2005). Large-scale identification of yeast integral membrane protein interactions. Proc Natl Acad Sci USA 102:12123–12128. 34. T. (1993). Correction of the class H defect in glycosylphosphatidylinositol anchor biosynthesis in Ltk-cells by a human cDNA clone.

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