Download Infectious Causes of Cancer: Targets for Intervention by James J. Goedert PDF

By James J. Goedert

James J. Goedert and a crew of top experimental and medical researchers offer severe, integrating surveys of these viruses, micro organism, and parasites which are referred to now to play an enormous function in cancer-work that opens the way in which towards novel healing objectives. The participants specialize in 5 different types of human carcinogenic infection-herpesviruses, retroviruses, papillomaviruses, hepatitis viruses, and H. pylori-and evaluation extensive the linked malignancies, in addition to how those new diagnostic and healing applied sciences should be applied. state-of-the-art and cross-disciplinary, Infectious reasons of melanoma: ambitions for Intervention presents medical oncologists and infectious affliction experts, in addition to medical researchers, with insightful experiences of melanoma induction by means of infectious illnesses and the excessive promise of heavily exact new therapeutics and vaccines.

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Additional info for Infectious Causes of Cancer: Targets for Intervention (Infectious Disease)

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VIRUSES AND MALIGNANCY Early Research Perhaps the first researcher to postulate a viral etiology for cancer was Amédée Borrel. He used the term “epitheliosis” for the cellular reaction to the invisible viruses responsible for such diseases as smallpox, cowpox, and sheep-pox, as early as 1903 (121). The term is based on the fact that these entities localize and proliferate in epithe- History of Infectious Disease Oncology 19 lial tissue (122). Considering the viral inclusions to be parasites, he found them analogous to those found in some malignancies, such as the contagious epithelioma of birds (123).

Watson, writing in his Lectures on the Principles and Practice of Physic, the most popular medical textbook of the period, also expressed the opinion that cancer may be a contagious entity. He stopped one step short of calling it an infectious disease, however. He cited two cases that he himself had witnessed, also cited by Wood, of uterine cancer in a wife and penile cancer in the husband. He also mentioned Langenbeck’s experiment, likewise cited by Wood. ” He saw plausible grounds for the hypothesis, that the seeds of cancer may be introduced, in some way which eludes observation, from without; that cancerous growths are strictly parasitic, and independent of the body, excepting so far as they derive their pabulum from its juices … But whether this hypothesis be true, or whether the cancer cells and germs are merely morbid elements of the native tissues of the body … remains yet to be determined.

He postulated that these organisms could possibly be the transmitters of human malignancy (95). Shattock was one of those who embraced a protozoal, rather than a bacterial, explanation of cancer. Work was pursued in this field in several laboratories around the turn of the century. A detailed discussion of this research is beyond the scope of this chapter, but is also described in great detail in the monograph by Wolff (96). Suffice it to say that, as was the case with bacteria, all attempts at finding a protozoal cause for cancer were in vain.

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