By Marco Malavolta PhD, Eugenio Mocchegiani MD
Molecular foundation of meals and getting older: A quantity within the Molecular nutrients sequence focuses at the dietary concerns linked to getting older and the real metabolic outcomes of nutrition, meals, and wellbeing and fitness. The publication is subdivided into 4 components that replicate the influence of meals from a biomolecular point to person future health.
In half One, chapters discover the final points of getting older, getting older phenotypes, and correct facets of nutrients concerning the aged and fit getting older. half comprises molecular and mobile pursuits of nutrients in getting older, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA harm and service, redox homeostasis, and insulin sensitivity, between others.
Part 3 appears at system-level and organ ambitions of nutrients in getting older, together with quite a few tissues, structures, and illnesses, akin to immune functionality, the cardiovascular approach, the mind and dementia, muscle, bone, lung, etc. ultimately, half 4 specializes in the healthiness results of particular nutritional compounds and nutritional interventions in getting older, together with diet D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, nutrition B, fish oil, nutrition E, resveratrol, polyphenols, greens, and fruit, in addition to the present dietary recommendations.
- Offers up to date details and a views on very important destiny advancements to various execs keen on the fundamental and medical examine on all significant dietary points of aging
- Explores how dietary elements are enthusiastic about the pathogenesis of getting older throughout physique systems
- Investigates the molecular and genetic foundation of getting older and mobile senescence during the lens of the quickly evolving box of molecular nutrition
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Extra info for Molecular Basis of Nutrition and Aging. A Volume in the Molecular Nutrition Series
In this kind of research, the object of the study is not longevity but extreme longevity: centenarian people are perfect models to understand the mechanisms behind aging process and their genetic make-up could reveal how to take advantage from these information for a good aging. The studies on other species’ genome have the same importance, because many of the mechanisms of aging are highly conserved between species and the use of a simpler and shorter-lived organism could give more complete results.
Besides cell division, various environmental, physiological, or psychological stressors may shorten telomeres. Targeting the latter may retard the signal for somatic cell senescence. Conversely, many tumoral cells exhibit telomerase activity or an alternative lengthening of telomeres that prevents telomere shortening, which is a means for the cells to escape telomere shortening-related apoptosis. Associative studies have shown that vitamins D and E, dietary fiber, and omega-3 fatty acid intakes in the diet correlated with longer telomeres.
I. INTRODUCTORY ASPECTS ON AGING AND NUTRITION REFERENCES  Ferguson LR, Fenech MF. Vitamin and minerals that influence genome integrity, and exposure/intake levels associated with DNA damage prevention. Mutat Res 2012;733(1-2):1À3.  Karunasinghe N, Ryan J, Tuckey J, Masters J, Jamieson M, Clarke LC, et al. DNA stability and serum selenium levels in a high-risk group for prostate cancer. Cancer Epidemiol Biomarkers Prev 2004;13(3):391À7.  Caple F, Williams EA, Spiers A, Tyson J, Burtle B, Daly AK, et al.