By S. Garagna
Reprint of: Cytogenetic and Genome study 2004, Vol. a hundred and five, No. 2-4 the home mouse holds a special position between version organisms, representing an fundamental software for plenty of investigators, rather in biomedical examine. Mouse genetics encompasses approximately a hundred years of analysis and culminated within the ebook of the mouse genome series in 2002, from which the belief for this detailed factor arose. the problem beneficial properties 37 peer-reviewed papers offering a wide-ranging evaluate of all significant elements of mouse genetics, from nuclear move and embryonic improvement to melanoma, from replica to speciation and sensible genomics applied sciences. Its objective is to offer an appropriate instrument of research for the massive inhabitants of researchers that use the mouse as a version animal. protecting a number of themes, this ebook could be an invaluable advisor for scientists operating within the fields of copy, improvement, evolution, melanoma, toxicology, and mobile biology in addition to for novices getting into the area of mouse genetics.
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Extra info for Mouse Genetics After The Mouse Genome: Cytogenetic And Genome Research 2004
Spermatogenesis culminates in spermiation, when spermatozoa are released from Sertoli cells into the lumen of the tubule. What happens as a result of vitamin A deficiency in testis? Early studies of the specific functions of vitamin A in reproduction were complicated by the overall poor health of VAD animals. , 1964). , 1989; Kim and Wang, 1993; Eskild and Hansson, 1994). For example, examination of the sequence and kinetics of spermatogenic cell disappearance following the onset of VAD revealed that all stages of spermatids in VAD rat testes decreased abruptly from day 2 following the initial loss of body weight (designated as the growth retardation phase of VAD).
Many retinoid-specific binding proteins have been identified, some of which are intracellular while others are extracellular. CRBP-I and CRBPII and cellular retinoic acid-binding protein, types I and II (CRABP-I and CRABP-II) are exclusively intracellular, whereas RBP, transthyretin (TTR) and interphotoreceptor retinoidbinding protein (IRBP) are extracellular. , 1994). RBP is the sole specific transport protein for retinol in the circulation and was proposed to have as its physiological function the delivery of retinol to tissues.
1994), suggesting a close association between the phosphorylation and localization of 7H6 antigen at TJ. Recently, it was reported that ATRA induced the TJ structure and expression of several TJassociated molecules, such as ZO-1, occludin, claudin-6, and claudin-7, as well as a barrier function in F9 murine EC cells. , 2001). A delay in the assembly of ZO-1, a peripheral component protein of TJ, into the Sertoli cell barrier has been detected in Rara–/– testis (SSWC and DJW, unpublished observations).