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Mild cognitive impairment in the elderly: Predictors of dementia. Neurology, 41, 1006-1009. , Meyer, T. , and Holloszy, J. O. (2004). Long-term calorie restriction is highly effective in reducing the risk of atherosclerosis in humans. Proceedings of the National Academy of Sciences, 101, 6659-6663. , and Winblad, B. (2000). Influence of social network on occurrence of dementia: A community-based longitudinal study. Lancet, 355, 1315-1319. , et al. (1999). Supraphysiological hyperinsulinemia acutely increases hypothalamic-pituitaryadrenal secretory activity in humans.

Insulin facilitates glucose uptake in the brain, modulates neurotransmitter levels, and affects neuronal function, including signaling pertinent to memory function. , 2008) insulin administration. Alzheimer’s disease patients, who likely have insulin resistance, require higher doses to achieve modest increments in memory function. Insulin enters the brain via a blood brain barrier transport mechanism (Banks, Jaspan, Huang and Kastin, 1997). , 1987). , 2002). BDNF supports existing and new neuron function, especially in the hippocampus and neocortex.

Low serum insulin in traditional Pacific Islanders: The Kitava Study. Metabolism, 48, 1216-1219. , and Lundh, B. (1993). Apparent absence of stroke and ischaemic heart disease in a traditional Melanesian island: A clinical study in Kitava. Journal of Internal Medicine, 233, 269-275. Luchsinger, J. , Manly, J. , and Mayeux, R. (2007). Relation of diabetes to Mild Cognitive Impairment. Archives of Neurology, 64, 570-575. , Cole, S. ,et al. (2007). Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.

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