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By Damianos E. Sakas, Brian A. Simpson

This is often the second one half in a two-volume paintings on neuromodulation. It describes the innovations and methods utilized by means of direct touch with the principal worried procedure or cranial nerves (in order to modulate the functionality of neural networks) or in deeply situated buildings contained in the worried process (in order to change the functionality on particular networks).

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Stereotact Funct Neurosurg 1994; 62: 295–299 [6] Yamamoto et al. Pain 1997; 72: 5–12 [7] Katayama et al. Stereotact Funct Neurosurg 1997; 69: 73–79 [8] Katayama et al. J Neurosurg 1998; 89: 585–591 [9] Katayama et al. Stereotact Funct Neurosurg 2001; 77: 159–162 [10] Katayama et al. Stereotact Funct Neurosurg 2001; 77: 183–186 [11] Fukaya et al. Neurol Res 2003; 25: 153–156 [12] Katayama et al. Acta Neurochir Suppl. 2003; 87: 121–123 [13] Canavero and Bonicalzi. J Neurosurg 1995; 83: 1117; [14] Canavero et al.

In 1993, Meyerson’s group reported extradural cortical stimulation effects in patients with neuropathic peripheral pain [8] and in 1995, we introduced the propofol test [3] and proved, contrary to current belief, that stimulation of the first somatosensory area (SI) (Brodmann’s areas 3,1,2) can have analgesic effects [4]. MCS gained wide acceptance and several hundred patients have been implanted with extradurally stimulating electrodes up to now [6, 8, 10, 11]. Mechanism of action The analgesic effect of CS appears to have a somatotopic organization.

Pool J, Clark W, Hudson P, Lombardo M (1956) Hypothalamichypophyseal interrelationships. Charles C Thomas Springfield 57. Pool JL (1954) Psychosurgery in older people. J Am Geriatr Soc 2: 456–466 58. Rainov NG, Fels C, Heidecke V, Burkert W (1997) Epidural electrical stimulation of the motor cortex in patients with facial neuralgia. Clin Neurol Neurosurg 99: 205–209 59. Reynolds DV (1969) Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science 164: 444–445 60. Rezai A, Lozano A (2002) Deep brain stimulation for chronic pain.

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