By Babak Arjmand
This publication covers a number of features of perinatal tissue-derived stem cells, from theoretical ideas to scientific purposes. themes contain features and diverse resources, immunomodulatory houses, translational viewpoint, GMP facility layout and production for medical translation, healing potentials, and eventually moral issues. The textual content presents a quick evaluate of every form of perinatal stem cells after which makes a speciality of their multi- or pluripotent homes, regenerative ability, and destiny healing strength in regenerative medication. also, the booklet discusses GMP compliance in stem mobilephone amenities and the manufacture of stem cells for scientific translation. The chapters are authored by way of world-renowned specialists within the perinatal stem phone box. Perinatal Tissue-Derived Stem Cells: replacement assets of Fetal Stem Cells, part of Springer’s Stem mobilephone Biology and Regenerative Medicine sequence, is vital interpreting for uncomplicated and scientific scientists, clinicians, and pharmaceutical specialists operating or accomplishing learn within the fields of stem phone biology, molecular facets of stem mobilephone study, tissue engineering, regenerative drugs, and mobile therapy.
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Extra info for Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells
Similar to bone marrow and other adult tissue isolated mesenchymal cells, they highly express CD90, CD73, CD105, and CD29 cell surface markers and do not express hematopoietic cell surface markers such as CD45, CD34, CD14, CD11b, and CD19 (Ilancheran et al. 2007; Roubelakis et al. 2012; Parolini et al. 2008). Human amniotic epithelial cells (hAEC) are separated by trypsin digestion of amniotic membrane which is mechanically separated from chorion. More enzymatic digestion with collagenase will terminate to complete isolation of AM-MSCs (In’t Anker et al.
Stem Cells Transl Med 1:725–731. 2012-0034 Taghizadeh RR, Cetrulo KJ, Cetrulo CL (2011) Wharton’s Jelly stem cells: future clinical applications. Placenta. 010 Takahashi N, Enosawa S, Mitani T, Lu H, Suzuki S, Amemiya H, Amano T, Sakuragawa N (2002) Transplantation of amniotic epithelial cells into fetal rat liver by in utero manipulation. Cell Transplant 11:443–449 Takashima S, Ise H, Zhao P, Akaike T, Nikaido T (2004) Human amniotic epithelial cells possess hepatocyte-like characteristics and functions.
In addition, they express high level of negative co-stimulatory Immunomodulatory Properties of Perinatal Tissue-Derived Stem Cells 31 molecules of B7H1, B7H2, B7H3, B7H4, and BTLA in the cell surface (Mooreﬁeld et al. 2011). Low immunogenicity of AF-MSCs introduced them as a source of allogeneic MSC transplantation, while cell surface expression of HLA-ABC and probable low level expression of class II HLA molecules promoted allo-antibody production (Schu et al. 2012). So it seems that they are suitable for autologous not allogeneic transplantation.