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By Who

This e-book studies on a Consultative assembly convened to debate options for making improvements to the standard and volume of healing antisera crucial medications for the potent therapy of suspected rabid puppy bites and envenoming via snakebites and scorpion stings. Inadequacies within the efficacy safeguard and construction of those antisera have created an important international public healthiness drawback specially in Africa and Asia. every year hundreds of thousands of individuals are bitten through canines or snakes or stung by way of scorpions and the failure to supply antisera bills not less than 150,000 lives and a minimum of as many situations of everlasting actual handicap. the answer to this drawback calls for a world attempt to advertise move of expertise to affected nations to enhance criteria during the who is prequalification scheme and to facilitate distribution of antisera and coaching of scientific team of workers of their optimum use.

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43. Burnouf T et al. (2004). Assessment of the viral safety of antivenoms fractionated from equine plasma. Biologicals, 32:115-128. 44. Warrell DA et al. (1974). Bites by the saw-scaled or carpet viper (Echis carinatus): trial of two specific antivenoms. British Medical Journal, 4(5942):437-40. 45. Smalligan R et al. (2004). Crotaline snake bite in the Ecuadorian Amazon: randomised double blind comparative trial of three South American polyspecific antivenoms. British Medical Journal, 329(7475), 1129.

161-172. 24. Jones RGA, Landon J (2003). A protocol for ‘enhanced pepsin digestion’: a step by step method for obtaining pure antibody fragments in high yield from serum. Journal of Immunological Methods, 275:239-250. 25. Dos Santos MC et al. (1989). Purification of F(ab’)2 anti-snake venom by caprylic acid: A fast method for obtaining IgG fragments with large neutralization activity, purity and yield. Toxicon, 27:297-303. 30 RABIES AND ENVENOMINGS 26. Rojas G, Jiménez JM, Gutiérrez JM (1994). Caprylic acid fractionation of hyperimmune horse plasma: description of a rapid procedure for antivenom production.

Journal of Immunological Methods, 275:239-250. 25. Dos Santos MC et al. (1989). Purification of F(ab’)2 anti-snake venom by caprylic acid: A fast method for obtaining IgG fragments with large neutralization activity, purity and yield. Toxicon, 27:297-303. 30 RABIES AND ENVENOMINGS 26. Rojas G, Jiménez JM, Gutiérrez JM (1994). Caprylic acid fractionation of hyperimmune horse plasma: description of a rapid procedure for antivenom production. Toxicon, 32:351-363. 27. Theakston RDG, Warrell DA, Griffiths E (2003).

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