By Choya Yoon, Mark H. Tuszynski (auth.), Rahul Jandial MD, PhD, Mike Y. Chen MD, PhD (eds.)
Editors wish that Regenerative Biology of the backbone and Spinal Cord appeals to the nostalgic sentiments of investigators and intellectuals in that it may be held in hand and supply a wide survey of innovative technology. whilst its chapters will be digitally bought for these verified within the box to refine specific wisdom pursuits or gaps. most significantly, we ask the reader, whomever that could be, to peruse with no prejudice as numerous extra chapters could have been written sooner than overall spinal regeneration is achieved.
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Extra resources for Regenerative Biology of the Spine and Spinal Cord
The mean age of patients at the injury was almost 33 years old. 3 Regenerative Biology a/the Spine and Spinal Cord, edited by Rahul Jandial and Mike Y. Chen. 102012 Landes Bioscience and Springer Science+Business Media. 16 STEM CELL BASED STRATEGIES FOR SPINAL CORD INJlJRY REPAIR 17 None of these estimates of incidence, nor further risk factor characterization ofthe affected population, include SCI in under-developed nations. Undertaking a systematic survey of SCI in an impoverished nation such as Haiti, recently devastated by a large earthquake, would be not only difficult but a poor use oflimited public health resources at this point in the country's development.
Science 2009; 326:298-301. 113. Raivich G, Bohatschek M, Da Costa C et al. The AP-l transcription factor c-Jun is required for eflicient axonal regeneration. Neuron 2004; 43:57-67. FRONTIERS OF SPINAL CORD AND SPINE REPAIR 15 114. Nadeau S, Hein P, Fernandes KJ et al. A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Mol Cell Neurosci 2005; 29:525-535. 115. Seijffers R, Allchorne AJ, Woolf CJ. The transcription factor ATF-3 promotes neurite outgrowth. Mol Cell Neurosci 2006; 32:143-154.
The natural properties of hydrogels, such as permeability to small molecules, viscoelastic behaviour, low interfacial tension with biological fluids and structural stability, make these materials suitable for the reconstitution ofthe cellular microenvironment after implantation. 18 Moreover, these characteristics determine the transport properties that allow the facile diffusion oflow molecular weight, water-soluble molecules through the polymer network, the exchange of nutrients with the surrounding tissue and the maintenance ofa chemical balance within the polymer matrix similar to the composition ofthe surrounding tissue.