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By Juan F. Macias, Ph.D. Nunez, Juan F. Macias Nuñez, J. Stewart Cameron

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374-375, edited by F. Henke and O. Lubarsch. Berlin; Springer F E R I O L I , M . E . and c o M O L L i , R . (1974). Changes of liver and kidney polyamine levels during ageing. Experimental Gerontology, 10, 13-15 F E T T E R M A N , C H . , P H I L I P P , F . j . s. (1965). The growth and maturation of human glomeruli and proximal convolutions from term to adulthood. Pediatrics, 35, 601-619 F L O O D , c, GHERONDACHE, c, p i N C u s , G . , T A I T , j . F . S. and w i L L o u G H B Y , s. (1967).

F . S. and w i L L o u G H B Y , s. (1967). The metabolism and secretion of aldosterone in elderly subjects. , R O S E N , H . A. and S Y , w. (1972). Functional defects in the aging kidney. Annals of Internal Medicine, 76, 41-45 F U R N O , A . (1909). Ricerche anatomo-pathologiche intorno al rene atrofico senile. K. (1982). Changes with age in the human kidney. Experimental Gerontology, 17, 321-331 G R I F F I T H S , G . j . o. F. (1975). Estimation of renal size from radiographs: is the effort worthwhile?

Urinary creatinine is almost entirely derived from the endogenous catabolism of muscle creatinine and phosphocreatinine. In humans, endogenous creatinine clearance closely approximates inulin clearance, in part as a result of compensatory errors (Brenner, Dworkin and Ichikawa, 1986). Urea, which has also been used as a marker for GFR measurement, shows major limitations because of the high degree of urea reabsorption by the renal tubules and the dependence of urea excretion on urine volume (Levinsky and Levy, 1973).

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