By Kelly Anne Hyndman, Thomas L. Pannabecker
This e-book provides innovative tools that supply insights into the pathways in which salt and water traverse telephone membranes and circulation in an orchestrated model among the numerous cubicles of the physique. It makes a speciality of a few molecular, mobile and entire animal reports that contain a number of physiological platforms and exhibits how the interior milieu is regulated by way of multifactorial gene legislation, molecular signaling, and mobilephone and organ architecture.
Topics lined contain: water channels, the urinary concentrating mechanism, angiotensin, the endothelin procedure, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The publication highlights how diversified techniques to explaining a similar physiological techniques drastically bring up our figuring out of those basic methods. higher integration of comparative, evolutionary and genetic animal versions in simple technological know-how and clinical technological know-how will enhance our total snatch of the mechanisms of sodium and water balance.
Read or Download Sodium and Water Homeostasis: Comparative, Evolutionary and Genetic Models PDF
Best health books
To mark the retirement of Dr Norman Sartorius in 1974 from his put up as Director of the department of psychological healthiness of the realm future health service provider, the editors (all long-standing advisors and collaborators with the WHO programme) have introduced jointly contributions from a mix of consultant, collaborators and WHO employees contributors.
The necessity for evidence-based judgements that take account of either effectiveness and economics is bigger now than ever. utilizing case reports and illustrative examples during the authors describe how the actions and outputs of proof synthesis, systematic overview, monetary research and decision-making have interaction inside and throughout diverse spheres of well-being and social coverage and perform.
This publication constitutes the refereed lawsuits of the overseas convention on mind and health and wellbeing Informatics, BHI 2013, held in Maebashi, Japan, in October 2013. The 33 revised complete papers awarded including eight workshop papers and 12 designated consultation papers have been conscientiously reviewed and chosen for inclusion within the publication.
OF 'SOLIDARITY' IN united kingdom SOCIAL WELFARE the following then, possibly, is a British model of team spirit in social welfare, yet early there are robust tensions among the powerfully liberal individualistic strands of the British realizing of the services of the nation and the socialistic or communitarian tendency of a dedication to common welfare provision.
- The 7-Day Allergy Makeover: A Simple Program to Eliminate Allergies and Restore Vibrant Health from the Inside Out
- Phytochemicals as Nutraceuticals - Global Apprs. to Their Role in Nutrition, Health
- The French Beauty Solution: Time-Tested Secrets to Look and Feel Beautiful Inside and Out
- Food poisoning : outbreaks, bacterial sources and adverse health effects
Additional resources for Sodium and Water Homeostasis: Comparative, Evolutionary and Genetic Models
Understanding the basic mechanisms of how water balance is maintained, or dysfunctional in certain diseases is thus of clinical importance. In recent years, application of transgenic and knockout mouse technology is providing critical new information about urinary concentrating processes and thus mechanisms for maintaining body water homeostasis. In this chapter we provide a brief overview of genetic mouse model generation, and then summarize findings in transgenic and knockout mice pertinent to our understanding of the urinary concentrating mechanism, focusing predominantly on mice in which expression of specific renal transporters or receptors has been deleted.
Aqp1 A full length cDNA cloned from quail kidney has 82 % sequence identity with rat Aqp1. qAqp1 was immunolocalized in the apical brush border membrane of proximal tubule cells but not in the basolateral membrane. Unlike mammalian nephrons, qAqp1 was not localized in the descending loop of Henle. In the house sparrow, Passer domesticus, an Aqp1 homolog was shown to be expressed in both the proximal and distal tubules in addition to podocytes of the glomerulus (Casotti et al. 2007). ” Further, there are no knock-out animals available to test this hypothesis.
Clin Exp Nephrol 13:107–117 Ishibashi K, Kondo S, Hara S, Morishita Y (2011) The evolutionary aspects of aquaporin family. Am J Physiol 300:R566–R576 Ishikawa Y, Yuan Z, Inuoe N, Skowronski MT, Nakae Y, Shono M, Cho G, Yasui M, Agre P, Nielsen S (2005) Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland. Am J Physiol Cell Physiol 289:C1303–C1311 Nollet (Abbe´) JA (1752) Investigations on the causes for the ebullition of liquids.