Download Systems, Part AB (Growth Factors & Cytokines in Health & by D. LeRoith, C. Bondy PDF

By D. LeRoith, C. Bondy

This quantity bargains with a few of the a number of platforms that development elements and cytokines impact. The function of development components and cytokines on foetal improvement, within the immune and haemopoietic structures in addition to within the skeletal and reproductive platforms are lined. a variety of cancers are tested in a few of the chapters. this is often the 3rd and concluding quantity of the treatise on progress elements and cytokines in health and wellbeing and disorder.

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Additional resources for Systems, Part AB (Growth Factors & Cytokines in Health & Disease) (Growth Factors & Cytokines in Health & Disease)

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2. 3. Stages of Hemochorial Placental Development That May Be Regulated by Growth Factors Formation of outer cell mass and proliferation of primitive trophoblasts. Differentiation into cyto- and syncitio-trophoblasts Migration and invasion of Intermediate (extravillous cytotrophoblasts) into maternal endometrium, formation of the trophoblastic shell 4. Modulation of immunity at the feto-maternal interface by interference with the development of immune responses by maternal T and B cells 5. Differentiation of maternal stroma into decldua 6.

1991a). , 1993). , 1994). , 1987). , 1989; Brunetti and Goldfine, 1990), suggesting that a widespread presence in vivo serves to prevent a premature differentiation of muscle. TGF-P also prevents terminal differentiation, but has little effect on proliferative rate. The onset of Growth Factors in the Fetus and Placenta 17 differentiation can therefore be finely controlled by relative changes in the abundance of particular growth factors in the microenvironment. These growth factor signals derive, in part, from the cells themselves in vitro.

1986). The synthesis of IGFs by the placentae is gestationally age dependent. , 1988). Human and rat placenta have been the source for cloning of IGFBP cDNAs indicating that placenta expresses IGFBP genes. In the mouse, IGFBP-2 is the most abundant IGFBP mRNA expressed, localized predominantly to the spongiotrophoblast cells immediately adjacent to the maternal decidua (Zhou and Bondy, 1992). , 1993). , 1984). , 1989). One of the most exciting findings is the clear demarcation in the cell types expressing IGFs and IGFBPs at the fetomaternal interface: IGF-II mRNA is abundant in the fetal intermediate trophoblasts and IGFBP mRNAs are abundant in the maternal decidua.

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