By Institute of Medicine, Board on Health Sciences Policy, Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy, Dan G. Blazer, Catharyn T. Liverman
Pop culture frequently equates testosterone with virility, power, and the macho male body. considered by means of a few as an "antiaging tonic," testosterone's recognition and elevated use via males of every age within the usa have outpaced the clinical proof approximately its power merits and dangers. specifically there was transforming into drawback approximately a rise within the variety of middle-aged and older males utilizing testosterone and the shortcoming of medical facts at the influence it might have on getting older men. stories of testosterone substitute remedy in older males have more often than not been of brief period, related to small numbers of contributors and infrequently missing enough controls. "Testosterone and getting older" weighs the choices of destiny learn instructions, examines the dangers and advantages of testosterone substitute remedy, assesses the aptitude public future health effect of such treatment within the usa, and considers moral matters on the topic of the behavior of scientific trials. Testosterone remedy is still an enticing choice to many males at the same time hypothesis abounds concerning its power.
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Additional info for Testosterone and Aging: Clinical Research Directions
In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, eds. Harrison’s Principles of Internal Medicine. 15th ed. New York: McGraw Hill. Pp. 2143–2154. Handelsman DJ. 1996. Androgen delivery systems: testosterone pellet implants. In: Bhasin S, Gabelnick HL, Spieler JM, Swerdloff JM, Wang C, Kelly C, eds. Pharmacology, Biology, and Clinical Applications of Androgens: Current Status and Future Prospects. New York: Wiley-Liss. Pp. 459–469. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR.
INTRODUCTION 23 and debilitating illnesses such as emphysema and cirrhosis. Testosterone is also being evaluated as a male hormonal contraceptive because it suppresses the production of pituitary gonadotropins and therefore spermatogenesis (Amory and Bremner, 2000). , 2001). This decrease in testosterone levels results from a decline in the testicular production of testosterone as well as from reduced hypothalamic secretion of gonadotropin-releasing hormone (and consequently reduced LH secretion by the pituitary) (Matsumoto, 2003).
Heaton JP. 2003. Hormone treatments and preventive strategies in the aging male: whom and when to treat? Reviews in Urology 5(S1):S16–S21. Hoberman JM, Yesalis CE. 1995. The history of synthetic testosterone. Scientific American 272(2):76–81. Kaufman JM, Vermeulen A. 1997. Declining gonadal function in elderly men. Bailliere’s Clinical Endocrinology and Metabolism 11(2):289–309. Malmström BG, Andersson B. 2003. The Nobel Prize in Chemistry: The Development of Modern Chemistry. [Online]. html [accessed May 2003].