Download The Intervertebral Disc: Molecular and Structural Studies of by Irving M. Shapiro, Makarand V. Risbud PDF

By Irving M. Shapiro, Makarand V. Risbud

The intervertebral disc is a posh constitution that separates opposing vertebrae, allows a variety of movement, and incorporates excessive biomechanical forces. Disc degeneration results in a lack of functionality and is frequently linked to excruciating pain.

Written by way of top scientists and clinicians, the 1st a part of the booklet presents a evaluate of the fundamental biology of the disc in overall healthiness and ailment. the second one half considers ideas to mitigate the results of disc degeneration and discusses the potential of engineering substitute tissues. the ultimate part is dedicated to methods to version common improvement and elucidate the pathogenesis of degenerative disc affliction utilizing animal, organ and cellphone tradition strategies.

The ebook bridges the distance among the elemental and scientific sciences; the objective viewers contains easy scientists, orthopaedists and neurologists, whereas whilst beautiful to the desires of graduate scholars, scientific scholars, interns and fellows.

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Additional info for The Intervertebral Disc: Molecular and Structural Studies of the Disc in Health and Disease

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2012). All the degenerative changes observed at the tissue level have an effect on the mechanics at the disc level. Of all of the tissues in the intervertebral disc, the most mechanically affected with degeneration is the nucleus pulposus. The loss of osmotic pressure and hydration in the center of disc leads Mechanically Induced Injury of the Intervertebral Disc Herniation Herniation is characterized by the prolapse of the nucleus pulposus through the annulus fibrosus. In vitro, herniation can be produced by a single high-intensity load or the repetitive application of forces with lower intensity (Callaghan and McGill 2001; Iencean 2000).

2006). It was concluded that the experimentally measured stiffness along the multidirectional axes do not match with the analytical predictions from the stiffness along principal axes (Spenciner et al. 2006). 4 Torsion During a twisting motion of the trunk, torsion becomes another important component of the loading of intervertebral discs. Similar to flexion/extension, torsion is defined as the relative rotation of consecutive vertebral bodies; however, the axis of rotation is parallel to the axis of the spine.

This test provides the aggregate modulus, measured as a function of strain. Similar to the nucleus pulposus, the mechanical behavior of the matrix depends on contributions from the osmotic pressure and the nonionic extrafibrillar matrix (Cortes and Elliott 2012). In this manner, the mechanical properties of this extrafibrillar matrix can be measured in tension and compression by applying osmotic swelling and confined compression simultaneously. The nonionic extrafibrillar matrix is nonlinear with a higher stiffness in compression (~50 kPa) than in tension (~10 kPa), and the contribution of the osmotic pressure in the support of the applied loads is high (~70 % of total) when the EFM is in compression and low (~25 %) when in tension.

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