By Lester Packer
This cutting edge reference explores a big variety of themes linked to getting older, delivering a superb realizing of the importance and molecular foundation of the getting older strategy and charting the process destiny study within the sector.
Stresses the interaction of mitochondria, mitochondrial DNA, oxidants, and antioxidants!
Featuring the examine of over fifty five specialists within the sector, knowing the method of Aging
Featuring over 1800 references, tables, drawings, and images, knowing the method of getting older merits nutritionists and dieticians, geriatricians, cellphone and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and clinical university scholars in those disciplines.
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Extra resources for Understanding the Process of Aging: The Roles of Mitochondria: Free Radicals, and Antioxidants
Mge... in antioxidant enzymes and proox ida m generation in rat tissues wi th reference to parameters in two insect species. Free Radic BioI Moo 1990: 9:495-500. 52. Rarja G, CadenfiS S, Rojas C, Perez-Campo R, Lopez-Torn~s M. Low mitochondrial free radical production per un it of 0 1 consu mption can explain the simullaneous presence o f high longevity and high aerobic metabolic rate in birds. Free Radic Res 1994: 2 1:3 17-328. 53. U esuy S. Evelson P. Gonzalez- A ec ha B. et aJ. Oxid3tive stress in muscle and li ver of rats with septic s), ndromc.
30. White CWo Ghezzi P. Dinarello CA. Caldwell SA. McMurtry IF. RepineJE. ed glutathione accumulation. lung injury. and mortality in rats exposed to hyperoxia. J Clin In\'est 1987; 79: 18bS-1873. 31. TangO. Berg n . White lE. Lumb PD. Lee CY. Tsan M. Protection against oxygen toxicity by trac heal insufnation of endotoxin: role of Mn SOD and alveolar ma<;TOphages. Am 1 Physiol 1994: 266(1O):L38- L45. 32. White CWo Lewis-Molock Y. Suzuki K. el al. 'Iion and immunohistochemical distri hUlion. Chest 1994; 105(3):855-865.
We had started with the surpri sing result that mitochondrial respiration increased oxidative stress in yeast that were deficient in Mn-SOD. but decreased oxidative stress in yeast that were deficient in C u,Zn-SOO. This ini tially paradoxical finding in vi vo was supported and explained by the isolated mitochondrial studies. Both yeast and mammalian mitochondria had a significant increase in superoxide scavenging during respiration compared 10 the resting stme. Antimycin. whic h inhibits electron transport and thus prevems proto n gradient generation.